(?) (?)摘(Zhai)要(Yao):(?)冷(Leng)冻(Dong)干(Gan)燥(Zao)机(Ji)(冷(Leng)干(Gan)机(Ji))系(Xi)由(You)制(Zhi)冷(Leng)系(Xi)统(Tong)、(?)真(Zhen)空(Kong)系(Xi)统(Tong)、(?)加(Jia)热(Re)系(Xi)统(Tong)、(?)电(Dian)器(Qi)仪(Yi)表(Biao)控(Kong)制(Zhi)系(Xi)统(Tong)所(Suo)组(Zu)成(Cheng)。(?)主(Zhu)要(Yao)部(Bu)件(Jian)为(Wei)干(Gan)燥(Zao)箱(Xiang)、(?)凝(Ning)结(Jie)器(Qi)、(?)冷(Leng)冻(Dong)机(Ji)组(Zu)、(?)真(Zhen)空(Kong)泵(Beng)加(Jia)热(Re)/冷(Leng)却(Que)装(Zhuang)置(Zhi)等(Deng)。(?)
(?) (?)一(Yi)、(?)真(Zhen)空(Kong)冷(Leng)冻(Dong)干(Gan)燥(Zao)的(De)定(Ding)义(Yi)与(Yu)优(You)点(Dian):(?)
(?) (?)制(Zhi)品(Pin)经(Jing)完(Wan)全(Quan)冻(Dong)结(Jie),(?)并(Bing)在(Zai)一(Yi)定(Ding)的(De)真(Zhen)空(Kong)条(Tiao)件(Jian)下(Xia)使(Shi)冰(Bing)晶(Jing)升(Sheng)华(Hua),(?)从(Cong)而(?)达(Da)到(Dao)低(Di)温(Wen)脱(Tuo)水(Shui)的(De)目(Mu)的(De),(?)此(Ci)过(Guo)程(Cheng)即(Ji)称(Cheng)为(Wei)冷(Leng)冻(Dong)干(Gan)燥(Zao)(Freeze-drying),(?)简(Jian)称(Cheng)冻(Dong)干(Gan)。(?)
(?) (?)冻(Dong)干(Gan)的(De)固(Gu)体(Ti)物(Wu)质(Zhi)由(You)于(Yu)微(Wei)小(Xiao)的(De)冰(Bing)晶(Jing)体(Ti)的(De)升(Sheng)华(Hua)而(?)呈(Cheng)现(Xian)多(Duo)孔(Kong)结(Jie)构(Gou),(?)并(Bing)保(Bao)持(Chi)原(Yuan)先(Xian)冻(Dong)结(Jie)时(Shi)的(De)体(Ti)积(Ji),(?)加(Jia)水(Shui)后(Hou)极(Ji)易(Yi)溶(Rong)解(Jie)而(?)复(Fu)原(Yuan),(?)制(Zhi)品(Pin)在(Zai)升(Sheng)华(Hua)过(Guo)程(Cheng)中(Zhong)温(Wen)度(Du)保(Bao)持(Chi)在(Zai)较(Jiao)低(Di)温(Wen)度(Du)状(Zhuang)态(Tai)下(Xia)(一(Yi)般(Ban)低(Di)于(Yu)-250C),(?)因(Yin)而(?)对(Dui)于(Yu)那(Na)些(Xie)不(Bu)耐(Nai)热(Re)的(De)物(Wu)质(Zhi),(?)诸(Zhu)如(Ru)酶(Mei)、(?)激(Ji)素(Su)、(?)核(He)酸(Suan)、(?)血(Xue)液(Ye)和(He)免(Mian)疫(Yi)制(Zhi)品(Pin)等(Deng)的(De)干(Gan)燥(Zao)尤(You)为(Wei)适(Shi)宜(Yi)。(?)干(Gan)燥(Zao)的(De)结(Jie)果(Guo)能(Neng)排(Pai)出(Chu)95~99%以(Yi)上(Shang)的(De)水(Shui)份(Fen),(?)有(You)利(Li)于(Yu)制(Zhi)品(Pin)的(De)长(Chang)期(Qi)保(Bao)存(Cun)。(?)制(Zhi)品(Pin)干(Gan)燥(Zao)过(Guo)程(Cheng)是(Shi)在(Zai)真(Zhen)空(Kong)条(Tiao)件(Jian)下(Xia)进(Jin)行(Xing)的(De),(?)故(Gu)不(Bu)易(Yi)氧(Yang)化(Hua)。(?)针(Zhen)对(Dui)部(Bu)分(Fen)生(Sheng)化(Hua)药(Yao)物(Wu)的(De)化(Hua)学(Xue)、(?)物(Wu)理(Li)、(?)生(Sheng)物(Wu)的(De)不(Bu)稳(Wen)定(Ding)性(Xing),(?)冻(Dong)干(Gan)已(Yi)被(Bei)实(Shi)践(Jian)证(Zheng)明(Ming)是(Shi)一(Yi)种(Zhong)非(Fei)常(Chang)有(You)效(Xiao)的(De)手(Shou)段(Duan)。(?)随(Sui)着(Zhuo)生(Sheng)化(Hua)药(Yao)物(Wu)与(Yu)生(Sheng)物(Wu)制(Zhi)剂(Ji)的(De)迅(Xun)速(Su)发(Fa)展(Zhan),(?)冻(Dong)干(Gan)技(Ji)术(Shu)将(Jiang)越(Yue)来(Lai)越(Yue)显(Xian)示(Shi)其(Qi)重(Zhong)要(Yao)性(Xing)与(Yu)优(You)越(Yue)性(Xing)。(?)
(?) (?)二(?)、(?)医(Yi)用(Yong)冷(Leng)冻(Dong)干(Gan)燥(Zao)机(Ji)的(De)结(Jie)构(Gou)与(Yu)功(Gong)能(Neng)简(Jian)介(Jie):(?)
(?) (?)医(Yi)用(Yong)冷(Leng)冻(Dong)干(Gan)燥(Zao)机(Ji)系(Xi)由(You)制(Zhi)冷(Leng)系(Xi)统(Tong)、(?)真(Zhen)空(Kong)系(Xi)统(Tong)、(?)加(Jia)热(Re)系(Xi)统(Tong)、(?)电(Dian)器(Qi)仪(Yi)表(Biao)控(Kong)制(Zhi)系(Xi)统(Tong)所(Suo)组(Zu)成(Cheng)。(?)主(Zhu)要(Yao)部(Bu)件(Jian)为(Wei)干(Gan)燥(Zao)箱(Xiang)、(?)凝(Ning)结(Jie)器(Qi)、(?)冷(Leng)冻(Dong)机(Ji)组(Zu)、(?)真(Zhen)空(Kong)泵(Beng)加(Jia)热(Re)/冷(Leng)却(Que)装(Zhuang)置(Zhi)等(Deng)。(?)
(?) (?)制(Zhi)品(Pin)的(De)冻(Dong)干(Gan)是(Shi)在(Zai)干(Gan)燥(Zao)箱(Xiang)中(Zhong)进(Jin)行(Xing),(?)干(Gan)燥(Zao)箱(Xiang)内(Nei)搁(Ge)板(Ban)采(Cai)用(Yong)不(Bu)锈(Xiu)钢(Gang)板(Ban)制(Zhi)成(Cheng),(?)内(Nei)有(You)媒(Mei)体(Ti)导(Dao)管(Guan)分(Fen)布(Bu)其(Qi)中(Zhong),(?)可(Ke)对(Dui)制(Zhi)品(Pin)进(Jin)行(Xing)冷(Leng)却(Que)或(Huo)热(Re),(?)干(Gan)燥(Zao)箱(Xiang)的(De)后(Hou)面(Mian)装(Zhuang)有(You)真(Zhen)空(Kong)传(Chuan)感(Gan)器(Qi),(?)它(Ta)将(Jiang)真(Zhen)空(Kong)度(Du)转(Zhuan)变(Bian)成(Cheng)电(Dian)讯(Xun)号(Hao),(?)箱(Xiang)门(Men)四(Si)周(Zhou)镶(Xiang)嵌(Qian)有(You)密(Mi)封(Feng)橡(Xiang)胶(Jiao)圈(Quan),(?)临(Lin)用(Yong)前(Qian)可(Ke)涂(Tu)以(Yi)真(Zhen)空(Kong)硅(Gui)脂(Zhi)保(Bao)证(Zheng)箱(Xiang)体(Ti)的(De)密(Mi)封(Feng)。(?)
(?) (?)凝(Ning)结(Jie)器(Qi)为(Wei)缠(Chan)绕(Rao)柱(Zhu)面(Mian)式(Shi),(?)不(Bu)锈(Xiu)钢(Gang)柱(Zhu)面(Mian)外(Wai)绕(Rao)有(You)多(Duo)组(Zu)冷(Leng)气(Qi)盘(Pan)管(Guan),(?)其(Qi)工(Gong)作(Zuo)温(Wen)度(Du)低(Di)于(Yu)干(Gan)燥(Zao)箱(Xiang)内(Nei)制(Zhi)品(Pin)的(De)温(Wen)度(Du),(?)低(Di)温(Wen)可(Ke)达(Da)-550C,(?)从(Cong)制(Zhi)品(Pin)中(Zhong)升(Sheng)华(Hua)出(Chu)来(Lai)的(De)水(Shui)蒸(Zheng)气(Qi)能(Neng)充(Chong)分(Fen)地(Di)凝(Ning)结(Jie)在(Zai)与(Yu)冷(Leng)盘(Pan)管(Guan)相(Xiang)接(Jie)触(Chu)的(De)不(Bu)锈(Xiu)钢(Gang)柱(Zhu)面(Mian)的(De)内(Nei)表(Biao)面(Mian)上(Shang),(?)从(Cong)而(?)保(Bao)证(Zheng)冻(Dong)干(Gan)过(Guo)程(Cheng)的(De)顺(Shun)利(Li)进(Jin)行(Xing),(?)光(Guang)滑(Hua)的(De)柱(Zhu)面(Mian)式(Shi)结(Jie)构(Gou)的(De)优(You)点(Dian)是(Shi)容(Rong)易(Yi)清(Qing)洁(Jie),(?)在(Zai)冻(Dong)干(Gan)结(Jie)束(Shu)后(Hou),(?)可(Ke)用(Yong)电(Dian)热(Re)将(Jiang)霜(Shuang)层(Ceng)除(Chu)去(Qu)。(?)
(?) (?)旋(Xuan)片(Pian)式(Shi)真(Zhen)空(Kong)泵(Beng)用(Yong)以(Yi)对(Dui)系(Xi)统(Tong)抽(Chou)真(Zhen)空(Kong),(?)在(Zai)机(Ji)械(Xie)泵(Beng)的(De)进(Jin)气(Qi)口(Kou)安(An)装(Zhuang)了(Liao)一(Yi)个(Ge)带(Dai)自(Zi)动(Dong)放(Fang)气(Qi)的(De)电(Dian)磁(Ci)真(Zhen)空(Kong)阀(Fa),(?)它(Ta)与(Yu)旋(Xuan)片(Pian)泵(Beng)为(Wei)同(Tong)一(Yi)电(Dian)源(Yuan)控(Kong)制(Zhi),(?)当(Dang)停(Ting)泵(Beng)时(Shi),(?)电(Dian)磁(Ci)阀(Fa)门(Men)自(Zi)动(Dong)关(Guan)闭(Bi),(?)同(Tong)时(Shi)向(Xiang)真(Zhen)空(Kong)泵(Beng)内(Nei)放(Fang)气(Qi),(?)既(Ji)保(Bao)护(Hu)了(Liao)真(Zhen)空(Kong)系(Xi)统(Tong),(?)又(You)防(Fang)止(Zhi)了(Liao)真(Zhen)空(Kong)泵(Beng)向(Xiang)系(Xi)统(Tong)返(Fan)油(You)。(?)
(?) (?)在(Zai)制(Zhi)冷(Leng)系(Xi)统(Tong)中(Zhong),(?)二(?)台(Tai)2.2Kw的(De)半(Ban)封(Feng)闭(Bi)冷(Leng)冻(Dong)机(Ji)并(Bing)联(Lian)使(Shi)用(Yong),(?)由(You)风(Feng)冷(Leng)凝(Ning)器(Qi)出(Chu)来(Lai)的(De)高(Gao)压(Ya)制(Zhi)冷(Leng)剂(Ji)液(Ye)体(Ti)(无(Wu)氟(Fu)制(Zhi)冷(Leng)剂(Ji)V55C),(?)经(Jing)过(Guo)干(Gan)燥(Zao)过(Guo)滤(Lu)器(Qi)及(Ji)电(Dian)磁(Ci)阀(Fa)到(Dao)达(Da)毛(Mao)细(Xi)管(Guan),(?)经(Jing)节(Jie)流(Liu)后(Hou)进(Jin)入(Ru)蒸(Zheng)发(Fa)器(Qi),(?)由(You)于(Yu)冷(Leng)冻(Dong)机(Ji)的(De)抽(Chou)吸(Xi)作(Zuo)用(Yong),(?)使(Shi)蒸(Zheng)发(Fa)器(Qi)内(Nei)的(De)压(Ya)力(Li)下(Xia)降(Jiang),(?)液(Ye)体(Ti)制(Zhi)冷(Leng)剂(Ji)吸(Xi)收(Shou)环(Huan)境(Jing)的(De)热(Re)量(Liang)而(?)迅(Xun)速(Su)沸(Fei)腾(Teng)蒸(Zheng)发(Fa)。(?)低(Di)压(Ya)制(Zhi)冷(Leng)剂(Ji)气(Qi)体(Ti)被(Bei)冷(Leng)冻(Dong)抽(Chou)回(Hui),(?)再(Zai)经(Jing)压(Ya)缩(Suo)成(Cheng)高(Gao)压(Ya)气(Qi)体(Ti),(?)完(Wan)成(Cheng)一(Yi)次(Ci)制(Zhi)冷(Leng)循(Xun)环(Huan),(?)加(Jia)热(Re)/冷(Leng)却(Que)装(Zhuang)置(Zhi)中(Zhong)的(De)冷(Leng)排(Pai)管(Guan)以(Yi)凝(Ning)结(Jie)器(Qi)中(Zhong)的(De)冷(Leng)排(Pai)管(Guan)以(Yi)及(Ji)凝(Ning)结(Jie)器(Qi)中(Zhong)的(De)冷(Leng)气(Qi)盘(Pan)管(Guan)恪(Ke)于(Yu)制(Zhi)冷(Leng)系(Xi)统(Tong)中(Zhong)蒸(Zheng)发(Fa),(?)它(Ta)们(Men)是(Shi)通(Tong)过(Guo)两(Liang)个(Ge)不(Bu)同(Tong)的(De)电(Dian)磁(Ci)阀(Fa)来(Lai)供(Gong)应(Ying)制(Zhi)冷(Leng)剂(Ji)的(De)。(?)
(?) (?)加(Jia)热(Re)系(Xi)统(Tong)由(You)电(Dian)热(Re)管(Guan),(?)媒(Mei)体(Ti)(硅(Gui)油(You))、(?)媒(Mei)体(Ti)泵(Beng)、(?)媒(Mei)体(Ti)箱(Xiang)等(Deng)组(Zu)成(Cheng)一(Yi)个(Ge)循(Xun)环(Huan)管(Guan)路(Lu),(?)硅(Gui)油(You)经(Jing)电(Dian)热(Re)管(Guan)加(Jia)热(Re)后(Hou),(?)由(You)媒(Mei)体(Ti)泵(Beng)输(Shu)送(Song)至(Zhi)干(Gan)箱(Xiang)搁(Ge)板(Ban)中(Zhong)的(De)媒(Mei)体(Ti)导(Dao)管(Guan),(?)对(Dui)制(Zhi)品(Pin)进(Jin)行(Xing)加(Jia)温(Wen),(?)提(Ti)供(Gong)升(Sheng)华(Hua)热(Re),(?)当(Dang)冻(Dong)结(Jie)时(Shi),(?)则(Ze)由(You)冷(Leng)却(Que)排(Pai)管(Guan)对(Dui)硅(Gui)油(You)进(Jin)行(Xing)降(Jiang)温(Wen),(?)由(You)媒(Mei)体(Ti)泵(Beng)输(Shu)送(Song)至(Zhi)干(Gan)燥(Zao)箱(Xiang)搁(Ge)板(Ban)中(Zhong)心(Xin)的(De)媒(Mei)体(Ti)导(Dao)管(Guan),(?)对(Dui)制(Zhi)品(Pin)进(Jin)行(Xing)冷(Leng)却(Que)及(Ji)冻(Dong)结(Jie)。(?)
(?) (?)电(Dian)器(Qi)仪(Yi)表(Biao)控(Kong)制(Zhi)系(Xi)统(Tong)为(Wei)机(Ji)电(Dian)一(Yi)体(Ti)化(Hua)设(She)计(Ji),(?)由(You)一(Yi)个(Ge)专(Zhuan)用(Yong)工(Gong)控(Kong)电(Dian)机(Ji)控(Kong)制(Zhi),(?)所(Suo)有(You)的(De)搁(Ge)板(Ban)温(Wen)度(Du)、(?)媒(Mei)体(Ti)温(Wen)度(Du)、(?)制(Zhi)品(Pin)温(Wen)度(Du)均(Jun)可(Ke)在(Zai)集(Ji)中(Zhong)的(De)显(Xian)示(Shi)上(Shang)显(Xian)示(Shi)出(Chu)来(Lai),(?)具(Ju)体(Ti)的(De)调(Diao)节(Jie)控(Kong)制(Zhi)请(Qing)参(Can)考(Kao)系(Xi)统(Tong)说(Shuo)明(Ming)书(Shu)。(?)
(?) (?)三(San)、(?)冻(Dong)干(Gan)的(De)基(Ji)本(Ben)原(Yuan)理(Li)与(Yu)实(Shi)践(Jian)
(?) (?)对(Dui)冻(Dong)干(Gan)制(Zhi)品(Pin)的(De)质(Zhi)量(Liang)要(Yao)求(Qiu)是(Shi):(?)生(Sheng)物(Wu)活(Huo)性(Xing)不(Bu)变(Bian)、(?)外(Wai)观(Guan)色(Se)泽(Ze)均(Jun)匀(Yun)、(?)形(Xing)态(Tai)饱(Bao)满(Man)、(?)结(Jie)构(Gou)牢(Lao)固(Gu)、(?)溶(Rong)解(Jie)速(Su)度(Du)快(Kuai),(?)残(Can)余(Yu)水(Shui)分(Fen)低(Di)。(?)要(Yao)获(Huo)得(De)高(Gao)质(Zhi)量(Liang)的(De)制(Zhi)品(Pin),(?)对(Dui)冻(Dong)干(Gan)的(De)理(Li)论(Lun)和(He)工(Gong)艺(Yi)应(Ying)有(You)一(Yi)个(Ge)比(Bi)较(Jiao)全(Quan)面(Mian)的(De)了(Liao)解(Jie)。(?)冻(Dong)干(Gan)工(Gong)艺(Yi)包(Bao)括(Kuo)预(Yu)冻(Dong)、(?)升(Sheng)华(Hua)和(He)再(Zai)干(Gan)冻(Dong)三(San)个(Ge)分(Fen)阶(Jie)段(Duan)。(?)合(He)理(Li)面(Mian)有(You)效(Xiao)地(Di)缩(Suo)短(Duan)冻(Dong)干(Gan)的(De)周(Zhou)期(Qi)在(Zai)工(Gong)业(Ye)生(Sheng)产(Chan)上(Shang)具(Ju)有(You)明(Ming)显(Xian)的(De)经(Jing)济(Ji)价(Jia)值(Zhi)。(?)
(?) (?)(一(Yi))制(Zhi)品(Pin)的(De)冻(Dong)结(Jie)
(?) (?)溶(Rong)液(Ye)速(Su)冻(Dong)时(Shi)(每(Mei)分(Fen)钟(Zhong)降(Jiang)温(Wen)10~50℃(?)),(?)晶(Jing)粒(Li)保(Bao)持(Chi)在(Zai)显(Xian)微(Wei)镜(Jing)下(Xia)可(Ke)见(Jian)的(De)大(Da)小(Xiao);相(Xiang)反(Fan)慢(Man)冻(Dong)时(Shi)(1℃(?)/分(Fen)),(?)形(Xing)成(Cheng)的(De)结(Jie)晶(Jing)肉(Rou)眼(Yan)可(Ke)见(Jian)。(?)粗(Cu)晶(Jing)在(Zai)升(Sheng)华(Hua)留(Liu)下(Xia)较(Jiao)大(Da)的(De)空(Kong)隙(Xi),(?)可(Ke)以(Yi)提(Ti)高(Gao)冻(Dong)干(Gan)的(De)效(Xiao)率(Lu),(?)细(Xi)晶(Jing)在(Zai)升(Sheng)华(Hua)后(Hou)留(Liu)下(Xia)的(De)间(Jian)隙(Xi)较(Jiao)小(Xiao),(?)使(Shi)下(Xia)层(Ceng)升(Sheng)华(Hua)受(Shou)阻(Zu),(?)速(Su)成(Cheng)冻(Dong)的(De)成(Cheng)品(Pin)粒(Li)子(Zi)细(Xi)腻(Ni),(?)外(Wai)观(Guan)均(Jun)匀(Yun),(?)比(Bi)表(Biao)面(Mian)积(Ji)大(Da),(?)多(Duo)孔(Kong)结(Jie)构(Gou)好(Hao),(?)溶(Rong)解(Jie)速(Su)度(Du)快(Kuai),(?)便(Bian)成(Cheng)品(Pin)的(De)引(Yin)湿(Shi)性(Xing)相(Xiang)对(Dui)也(Ye)要(Yao)强(Qiang)些(Xie)。(?)
(?) (?)药(Yao)品(Pin)在(Zai)冻(Dong)干(Gan)机(Ji)中(Zhong)预(Yu)冻(Dong)在(Zai)两(Liang)种(Zhong)方(Fang)式(Shi):(?)一(Yi)种(Zhong)是(Shi)制(Zhi)品(Pin)与(Yu)干(Gan)燥(Zao)箱(Xiang)同(Tong)时(Shi)降(Jiang)温(Wen),(?);另(Ling)一(Yi)种(Zhong)是(Shi)待(Dai)干(Gan)燥(Zao)箱(Xiang)搁(Ge)板(Ban)降(Jiang)温(Wen)至(Zhi)-40℃(?)左(Zuo)右(You),(?)再(Zai)将(Jiang)制(Zhi)品(Pin)放(Fang)入(Ru),(?)前(Qian)者(Zhe)相(Xiang)当(Dang)于(Yu)慢(Man)冻(Dong),(?)后(Hou)者(Zhe)则(Ze)介(Jie)于(Yu)冻(Dong)与(Yu)慢(Man)冻(Dong)之(Zhi)间(Jian),(?)因(Yin)而(?)常(Chang)被(Bei)采(Cai)用(Yong),(?)以(Yi)兼(Jian)顾(Gu)冻(Dong)干(Gan)效(Xiao)率(Lu)与(Yu)产(Chan)品(Pin)质(Zhi)量(Liang)。(?)此(Ci)法(Fa)的(De)缺(Que)点(Dian)是(Shi)制(Zhi)品(Pin)入(Ru)箱(Xiang)时(Shi),(?)空(Kong)气(Qi)中(Zhong)的(De)水(Shui)蒸(Zheng)气(Qi)将(Jiang)迅(Xun)速(Su)地(Di)凝(Ning)结(Jie)在(Zai)搁(Ge)板(Ban)上(Shang),(?)而(?)在(Zai)升(Sheng)华(Hua)初(Chu)期(Qi),(?)若(Ruo)板(Ban)升(Sheng)温(Wen)较(Jiao)快(Kuai),(?)由(You)于(Yu)大(Da)面(Mian)积(Ji)的(De)升(Sheng)华(Hua)将(Jiang)有(You)可(Ke)能(Neng)超(Chao)越(Yue)凝(Ning)结(Jie)器(Qi)的(De)正(Zheng)常(Chang)负(Fu)荷(He)。(?)此(Ci)现(Xian)象(Xiang)在(Zai)夏(Xia)季(Ji)尤(You)为(Wei)显(Xian)著(Zhu)。(?)
(?) (?)制(Zhi)品(Pin)的(De)冻(Dong)结(Jie)处(Chu)于(Yu)静(Jing)止(Zhi)状(Zhuang)态(Tai)。(?)经(Jing)验(Yan)证(Zheng)明(Ming),(?)过(Guo)冷(Leng)现(Xian)象(Xiang)容(Rong)易(Yi)发(Fa)生(Sheng)至(Zhi)使(Shi)制(Zhi)品(Pin)温(Wen)度(Du)虽(Sui)已(Yi)达(Da)到(Dao)共(Gong)晶(Jing)点(Dian)。(?)但(Dan)溶(Rong)质(Zhi)仍(Reng)不(Bu)结(Jie)晶(Jing),(?)为(Wei)了(Liao)克(Ke)服(Fu)过(Guo)冷(Leng)现(Xian)象(Xiang),(?)制(Zhi)品(Pin)冻(Dong)结(Jie)的(De)温(Wen)度(Du)应(Ying)低(Di)于(Yu)共(Gong)晶(Jing)点(Dian)以(Yi)下(Xia)一(Yi)个(Ge)范(Fan)围(Wei),(?)并(Bing)需(Xu)保(Bao)持(Chi)一(Yi)段(Duan)时(Shi)间(Jian),(?)以(Yi)待(Dai)制(Zhi)品(Pin)完(Wan)全(Quan)冻(Dong)结(Jie)。(?)
(?) (?)(二(?))升(Sheng)华(Hua)的(De)条(Tiao)件(Jian)与(Yu)速(Su)度(Du)
(?) (?)冰(Bing)在(Zai)一(Yi)定(Ding)温(Wen)度(Du)下(Xia)的(De)饱(Bao)和(He)蒸(Zheng)汽(Qi)压(Ya)大(Da)于(Yu)环(Huan)境(Jing)的(De)水(Shui)蒸(Zheng)气(Qi)分(Fen)压(Ya)时(Shi)即(Ji)可(Ke)开(Kai)始(Shi)升(Sheng)华(Hua);比(Bi)制(Zhi)品(Pin)温(Wen)更(Geng)低(Di)的(De)凝(Ning)结(Jie)器(Qi)对(Dui)水(Shui)水(Shui)蒸(Zheng)气(Qi)的(De)抽(Chou)吸(Xi)与(Yu)捕(Bu)获(Huo)作(Zuo)用(Yong),(?)则(Ze)是(Shi)维(Wei)护(Hu)升(Sheng)所(Suo)必(Bi)需(Xu)的(De)条(Tiao)件(Jian)。(?)
(?) (?)气(Qi)体(Ti)分(Fen)子(Zi)在(Zai)两(Liang)次(Ci)连(Lian)续(Xu)碰(Peng)撞(Zhuang)之(Zhi)间(Jian)所(Suo)走(Zou)的(De)距(Ju)离(Li)称(Cheng)为(Wei)平(Ping)均(Jun)自(Zi)由(You)程(Cheng),(?)它(Ta)与(Yu)压(Ya)力(Li)成(Cheng)反(Fan)比(Bi)。(?)在(Zai)常(Chang)压(Ya)下(Xia),(?)其(Qi)值(Zhi)很(Hen)小(Xiao),(?)升(Sheng)华(Hua)的(De)水(Shui)分(Fen)子(Zi)很(Hen)容(Rong)易(Yi)与(Yu)气(Qi)体(Ti)碰(Peng)撞(Zhuang)又(You)返(Fan)回(Hui)到(Dao)蒸(Zheng)汽(Qi)源(Yuan)表(Biao)面(Mian),(?)因(Yin)而(?)升(Sheng)华(Hua)速(Su)度(Du)很(Hen)漫(Man)。(?)随(Sui)着(Zhuo)压(Ya)力(Li)降(Jiang)低(Di)13.3Pa以(Yi)下(Xia),(?)平(Ping)均(Jun)自(Zi)由(You)程(Cheng)增(Zeng)大(Da)105倍(Bei),(?)使(Shi)升(Sheng)华(Hua)速(Su)度(Du)显(Xian)著(Zhu)加(Jia)快(Kuai),(?)飞(Fei)离(Li)出(Chu)来(Lai)的(De)水(Shui)分(Fen)子(Zi)很(Hen)少(Shao)改(Gai)变(Bian)自(Zi)己(Ji)的(De)方(Fang)面(Mian),(?)从(Cong)而(?)形(Xing)成(Cheng)了(Liao)定(Ding)向(Xiang)的(De)蒸(Zheng)汽(Qi)流(Liu)。(?)
(?) (?)真(Zhen)空(Kong)泵(Beng)在(Zai)冻(Dong)干(Gan)机(Ji)中(Zhong)起(Qi)着(Zhuo)抽(Chou)除(Chu)永(Yong)久(Jiu)气(Qi)体(Ti)的(De)作(Zuo)用(Yong),(?)以(Yi)维(Wei)护(Hu)升(Sheng)华(Hua)所(Suo)必(Bi)需(Xu)的(De)低(Di)压(Ya)强(Qiang)。(?)1g水(Shui)蒸(Zheng)气(Qi)在(Zai)常(Chang)压(Ya)下(Xia)为(Wei)1.25L而(?)在(Zai)13.3Pa时(Shi)却(Que)膨(Peng)胀(Zhang)为(Wei)10000升(Sheng),(?)普(Pu)通(Tong)的(De)真(Zhen)空(Kong)泵(Beng)在(Zai)单(Dan)位(Wei)时(Shi)间(Jian)内(Nei)抽(Chou)除(Chu)如(Ru)此(Ci)大(Da)量(Liang)的(De)体(Ti)积(Ji)是(Shi)不(Bu)可(Ke)能(Neng)的(De)。(?)凝(Ning)结(Jie)器(Qi)实(Shi)际(Ji)上(Shang)形(Xing)成(Cheng)了(Liao)专(Zhuan)门(Men)捕(Bu)集(Ji)水(Shui)蒸(Zheng)气(Qi)的(De)真(Zhen)空(Kong)泵(Beng)。(?)
(?) (?)制(Zhi)品(Pin)与(Yu)凝(Ning)结(Jie)的(De)温(Wen)度(Du)通(Tong)常(Chang)为(Wei)-25℃(?)与(Yu)-50℃(?)。(?)冰(Bing)在(Zai)该(Gai)温(Wen)度(Du)下(Xia)的(De)饱(Bao)和(He)蒸(Zheng)汽(Qi)压(Ya)分(Fen)别(Bie)为(Wei)63.3Pa与(Yu)1.1Pa,因(Yin)而(?)在(Zai)升(Sheng)华(Hua)面(Mian)与(Yu)冷(Leng)凝(Ning)面(Mian)之(Zhi)间(Jian)便(Bian)产(Chan)生(Sheng)了(Liao)一(Yi)个(Ge)相(Xiang)当(Dang)大(Da)的(De)压(Ya)力(Li)差(Cha),如(Ru)果(Guo)此(Ci)时(Shi)系(Xi)统(Tong)内(Nei)的(De)不(Bu)凝(Ning)性(Xing)气(Qi)体(Ti)分(Fen)压(Ya)可(Ke)以(Yi)忽(Hu)略(Lue)不(Bu)计(Ji),它(Ta)将(Jiang)促(Cu)使(Shi)制(Zhi)品(Pin)升(Sheng)华(Hua)出(Chu)来(Lai)的(De)水(Shui)蒸(Zheng)气(Qi),以(Yi)一(Yi)定(Ding)的(De)流(Liu)速(Su)定(Ding)向(Xiang)地(Di)抵(Di)达(Da)凝(Ning)结(Jie)器(Qi)表(Biao)面(Mian)结(Jie)成(Cheng)冰(Bing)霜(Shuang)。(?)
(?) (?)冰(Bing)的(De)升(Sheng)华(Hua)热(Re)约(Yue)为(Wei)2822J/克(Ke),(?)如(Ru)果(Guo)升(Sheng)华(Hua)过(Guo)程(Cheng)不(Bu)供(Gong)给(Gei)热(Re)量(Liang),(?)那(Na)末(Mo)制(Zhi)品(Pin)只(Zhi)有(You)降(Jiang)低(Di)内(Nei)能(Neng)来(Lai)补(Bu)偿(Chang)升(Sheng)华(Hua)热(Re),(?)直(Zhi)至(Zhi)其(Qi)温(Wen)度(Du)与(Yu)凝(Ning)结(Jie)器(Qi)温(Wen)度(Du)平(Ping)衡(Heng)后(Hou),(?)升(Sheng)华(Hua)也(Ye)就(Jiu)停(Ting)止(Zhi)了(Liao)。(?)为(Wei)了(Liao)保(Bao)持(Chi)升(Sheng)华(Hua)与(Yu)冷(Leng)凝(Ning)来(Lai)的(De)温(Wen)度(Du)差(Cha),(?)必(Bi)须(Xu)对(Dui)制(Zhi)品(Pin)提(Ti)供(Gong)足(Zu)够(Gou)的(De)热(Re)量(Liang)。(?)
(?) (?)(三(San))升(Sheng)华(Hua)过(Guo)程(Cheng)
(?) (?)在(Zai)升(Sheng)温(Wen)的(De)第(Di)一(Yi)阶(Jie)段(Duan)(大(Da)量(Liang)升(Sheng)华(Hua)阶(Jie)段(Duan)),(?)制(Zhi)品(Pin)温(Wen)度(Du)要(Yao)低(Di)于(Yu)其(Qi)共(Gong)晶(Jing)点(Dian)一(Yi)个(Ge)范(Fan)围(Wei)。(?)因(Yin)此(Ci)搁(Ge)板(Ban)温(Wen)要(Yao)加(Jia)以(Yi)控(Kong)制(Zhi),(?)若(Ruo)制(Zhi)品(Pin)已(Yi)经(Jing)部(Bu)分(Fen)干(Gan)燥(Zao),(?)但(Dan)温(Wen)度(Du)却(Que)超(Chao)过(Guo)了(Liao)其(Qi)共(Gong)晶(Jing)点(Dian),(?)此(Ci)时(Shi)将(Jiang)发(Fa)生(Sheng)制(Zhi)品(Pin)融(Rong)化(Hua)现(Xian)象(Xiang),(?)而(?)此(Ci)时(Shi)融(Rong)化(Hua)的(De)液(Ye)体(Ti),(?)对(Dui)冰(Bing)饱(Bao)和(He),(?)对(Dui)溶(Rong)质(Zhi)却(Que)未(Wei)饱(Bao)和(He),(?)因(Yin)而(?)干(Gan)燥(Zao)的(De)溶(Rong)质(Zhi)将(Jiang)迅(Xun)速(Su)溶(Rong)解(Jie)进(Jin)去(Qu),(?)终(Zhong)于(Yu)浓(Nong)缩(Suo)成(Cheng)一(Yi)薄(Bao)僵(Jiang)块(Kuai),(?)外(Wai)观(Guan)极(Ji)为(Wei)不(Bu)良(Liang),(?)溶(Rong)解(Jie)速(Su)度(Du)很(Hen)差(Cha),(?)若(Ruo)制(Zhi)品(Pin)的(De)融(Rong)化(Hua)发(Fa)生(Sheng)在(Zai)大(Da)量(Liang)升(Sheng)华(Hua)后(Hou)期(Qi),(?)则(Ze)由(You)于(Yu)融(Rong)化(Hua)的(De)液(Ye)体(Ti)数(Shu)量(Liang)较(Jiao)少(Shao),(?)因(Yin)而(?)被(Bei)干(Gan)燥(Zao)的(De)孔(Kong)性(Xing)固(Gu)体(Ti)所(Suo)吸(Xi)收(Shou),(?)造(Zao)成(Cheng)冻(Dong)干(Gan)后(Hou)块(Kuai)状(Zhuang)物(Wu)有(You)所(Suo)缺(Que)损(Sun),(?)加(Jia)水(Shui)溶(Rong)解(Jie)时(Shi)仍(Reng)能(Neng)发(Fa)现(Xian)溶(Rong)解(Jie)速(Su)度(Du)较(Jiao)慢(Man)。(?)
(?) (?)在(Zai)大(Da)量(Liang)升(Sheng)华(Hua)过(Guo)程(Cheng),(?)虽(Sui)然(Ran)搁(Ge)板(Ban)和(He)制(Zhi)品(Pin)温(Wen)度(Du)有(You)很(Hen)大(Da)悬(Xuan)殊(Shu),(?)但(Dan)由(You)于(Yu)板(Ban)温(Wen)、(?)凝(Ning)结(Jie)器(Qi)温(Wen)度(Du)和(He)真(Zhen)空(Kong)温(Wen)度(Du)基(Ji)本(Ben)不(Bu)变(Bian),(?)因(Yin)而(?)升(Sheng)华(Hua)吸(Xi)热(Re)比(Bi)较(Jiao)稳(Wen)定(Ding),(?)制(Zhi)品(Pin)温(Wen)度(Du)相(Xiang)对(Dui)恒(Heng)定(Ding)。(?)随(Sui)着(Zhuo)制(Zhi)品(Pin)自(Zi)上(Shang)而(?)下(Xia)层(Ceng)层(Ceng)干(Gan)燥(Zao),(?)冰(Bing)层(Ceng)升(Sheng)华(Hua)的(De)阻(Zu)力(Li)逐(Zhu)渐(Jian)增(Zeng)大(Da)。(?)制(Zhi)品(Pin)温(Wen)度(Du)相(Xiang)应(Ying)也(Ye)会(Hui)小(Xiao)幅(Fu)上(Shang)升(Sheng)。(?)直(Zhi)至(Zhi)用(Yong)肉(Rou)眼(Yan)已(Yi)不(Bu)到(Dao)冰(Bing)晶(Jing)的(De)存(Cun)在(Zai)。(?)此(Ci)时(Shi)90%以(Yi)上(Shang)的(De)水(Shui)分(Fen)已(Yi)除(Chu)去(Qu)。(?)大(Da)量(Liang)升(Sheng)华(Hua)的(De)过(Guo)程(Cheng)至(Zhi)此(Ci)已(Yi)基(Ji)本(Ben)结(Jie)束(Shu),(?)为(Wei)了(Liao)确(Que)保(Bao)整(Zheng)箱(Xiang)制(Zhi)品(Pin)大(Da)量(Liang)升(Sheng)华(Hua)完(Wan)毕(Bi),(?)板(Ban)温(Wen)仍(Reng)需(Xu)保(Bao)持(Chi)一(Yi)个(Ge)阶(Jie)段(Duan)后(Hou)再(Zai)进(Jin)行(Xing)第(Di)二(?)阶(Jie)段(Duan)的(De)升(Sheng)温(Wen)。(?)
(?) (?)剩(Sheng)余(Yu)百(Bai)分(Fen)之(Zhi)几(Ji)的(De)水(Shui)分(Fen)称(Cheng)残(Can)余(Yu)水(Shui)分(Fen),(?)它(Ta)与(Yu)自(Zi)由(You)状(Zhuang)态(Tai)的(De)水(Shui)在(Zai)物(Wu)理(Li)化(Hua)学(Xue)性(Xing)质(Zhi)上(Shang)有(You)所(Suo)不(Bu)同(Tong),(?)残(Can)余(Yu)水(Shui)分(Fen)包(Bao)括(Kuo)了(Liao)化(Hua)学(Xue)结(Jie)合(He)之(Zhi)水(Shui)与(Yu)物(Wu)理(Li)结(Jie)合(He)之(Zhi)水(Shui),(?)诸(Zhu)如(Ru)化(Hua)合(He)的(De)结(Jie)晶(Jing)水(Shui)结(Jie)晶(Jing)、(?)蛋(Dan)白(Bai)质(Zhi)通(Tong)过(Guo)氢(Qing)键(Jian)结(Jie)合(He)的(De)水(Shui)以(Yi)及(Ji)固(Gu)体(Ti)表(Biao)面(Mian)或(Huo)毛(Mao)细(Xi)管(Guan)中(Zhong)吸(Xi)附(Fu)水(Shui)等(Deng)。(?)由(You)于(Yu)残(Can)余(Yu)水(Shui)分(Fen)受(Shou)到(Dao)种(Zhong)引(Yin)力(Li)的(De)束(Shu)缚(Fu),(?)其(Qi)饱(Bao)和(He)蒸(Zheng)汽(Qi)压(Ya)则(Ze)是(Shi)不(Bu)同(Tong)程(Cheng)度(Du)的(De)降(Jiang)低(Di),(?)因(Yin)而(?)干(Gan)燥(Zao)速(Su)度(Du)明(Ming)显(Xian)下(Xia)降(Jiang)。(?)虽(Sui)然(Ran)提(Ti)高(Gao)制(Zhi)品(Pin)温(Wen)度(Du)促(Cu)进(Jin)残(Can)余(Yu)水(Shui)分(Fen)的(De)气(Qi)化(Hua),(?)但(Dan)若(Ruo)超(Chao)过(Guo)某(Mou)极(Ji)限(Xian)温(Wen)度(Du),(?)生(Sheng)物(Wu)活(Huo)性(Xing)也(Ye)可(Ke)能(Neng)急(Ji)剧(Ju)下(Xia)降(Jiang)。(?)保(Bao)证(Zheng)制(Zhi)品(Pin)安(An)全(Quan)的(De)干(Gan)燥(Zao)温(Wen)度(Du)要(Yao)由(You)实(Shi)验(Yan)来(Lai)确(Que)定(Ding)。(?)通(Tong)常(Chang)我(Wo)们(Men)在(Zai)第(Di)二(?)阶(Jie)段(Duan)将(Jiang)板(Ban)温(Wen)+30℃(?)左(Zuo)右(You),(?)并(Bing)保(Bao)持(Chi)恒(Heng)定(Ding)。(?)在(Zai)这(Zhe)一(Yi)阶(Jie)段(Duan)初(Chu)期(Qi),(?)由(You)于(Yu)板(Ban)温(Wen)升(Sheng)高(Gao),(?)残(Can)余(Yu)水(Shui)分(Fen)少(Shao)又(You)不(Bu)易(Yi)气(Qi)化(Hua),(?)因(Yin)此(Ci)制(Zhi)品(Pin)温(Wen)度(Du)上(Shang)升(Sheng)较(Jiao)快(Kuai)。(?)但(Dan)随(Sui)着(Zhuo)制(Zhi)品(Pin)温(Wen)度(Du)与(Yu)板(Ban)温(Wen)逐(Zhu)渐(Jian)靠(Kao)拢(Long),(?)热(Re)传(Chuan)导(Dao)变(Bian)得(De)更(Geng)为(Wei)缓(Huan)慢(Man),(?)需(Xu)要(Yao)耐(Nai)心(Xin)等(Deng)待(Dai)相(Xiang)当(Dang)长(Chang)的(De)一(Yi)段(Duan)时(Shi)间(Jian),(?)实(Shi)践(Jian)经(Jing)验(Yan)表(Biao)明(Ming),(?)残(Can)余(Yu)水(Shui)分(Fen)干(Gan)燥(Zao)的(De)时(Shi)间(Jian)与(Yu)大(Da)量(Liang)升(Sheng)华(Hua)的(De)时(Shi)间(Jian)几(Ji)乎(Hu)相(Xiang)等(Deng)有(You)时(Shi)甚(Shen)至(Zhi)还(Huan)会(Hui)超(Chao)过(Guo)。(?)
(?) (?)(四(Si))冻(Dong)干(Gan)曲(Qu)线(Xian):(?)将(Jiang)搁(Ge)板(Ban)温(Wen)度(Du)与(Yu)制(Zhi)品(Pin)温(Wen)度(Du)随(Sui)时(Shi)间(Jian)的(De)变(Bian)化(Hua)记(Ji)录(Lu)下(Xia)来(Lai),(?)即(Ji)可(Ke)得(De)到(Dao)冻(Dong)干(Gan)曲(Qu)线(Xian)。(?)
(?) (?)比(Bi)较(Jiao)典(Dian)型(Xing)的(De)冻(Dong)干(Gan)曲(Qu)线(Xian)系(Xi)将(Jiang)搁(Ge)板(Ban)升(Sheng)温(Wen)分(Fen)为(Wei)两(Liang)个(Ge)阶(Jie)段(Duan),(?)在(Zai)大(Da)量(Liang)升(Sheng)华(Hua)时(Shi)搁(Ge)板(Ban)温(Wen)度(Du)保(Bao)持(Chi)较(Jiao)低(Di),(?)根(Gen)据(Ju)实(Shi)际(Ji)情(Qing)况(Kuang),(?)一(Yi)般(Ban)可(Ke)控(Kong)制(Zhi)在(Zai)-10至(Zhi)+10之(Zhi)间(Jian)。(?)第(Di)二(?)阶(Jie)段(Duan)则(Ze)根(Gen)据(Ju)制(Zhi)品(Pin)性(Xing)质(Zhi)将(Jiang)搁(Ge)板(Ban)温(Wen)度(Du)适(Shi)当(Dang)调(Diao)高(Gao),(?)此(Ci)法(Fa)适(Shi)用(Yong)于(Yu)其(Qi)熔(Rong)点(Dian)较(Jiao)低(Di)的(De)制(Zhi)品(Pin)。(?)若(Ruo)对(Dui)制(Zhi)品(Pin)的(De)性(Xing)能(Neng)尚(Shang)不(Bu)清(Qing)楚(Chu),(?)机(Ji)器(Qi)性(Xing)能(Neng)较(Jiao)差(Cha)或(Huo)其(Qi)工(Gong)作(Zuo)不(Bu)够(Gou)稳(Wen)定(Ding)时(Shi),(?)用(Yong)此(Ci)法(Fa)也(Ye)比(Bi)较(Jiao)稳(Wen)妥(Tuo)。(?)
(?) (?)如(Ru)果(Guo)制(Zhi)品(Pin)共(Gong)晶(Jing)点(Dian)较(Jiao)高(Gao),(?)系(Xi)统(Tong)的(De)真(Zhen)空(Kong)度(Du)也(Ye)能(Neng)保(Bao)持(Chi)良(Liang)好(Hao),(?)凝(Ning)结(Jie)器(Qi)的(De)制(Zhi)冷(Leng)能(Neng)力(Li)充(Chong)裕(Yu),(?)则(Ze)也(Ye)可(Ke)采(Cai)用(Yong)一(Yi)定(Ding)的(De)升(Sheng)温(Wen)速(Su)度(Du),(?)将(Jiang)搁(Ge)板(Ban)温(Wen)度(Du)升(Sheng)高(Gao)至(Zhi)允(Yun)许(Xu)的(De)温(Wen)度(Du),(?)直(Zhi)至(Zhi)冻(Dong)干(Gan)结(Jie)束(Shu),(?)但(Dan)也(Ye)需(Xu)保(Bao)证(Zheng)制(Zhi)品(Pin)在(Zai)大(Da)量(Liang)升(Sheng)华(Hua)时(Shi)的(De)温(Wen)度(Du)不(Bu)得(De)超(Chao)过(Guo)共(Gong)晶(Jing)点(Dian)。(?)
(?) (?)若(Ruo)制(Zhi)品(Pin)对(Dui)热(Re)不(Bu)稳(Wen)定(Ding),(?)则(Ze)第(Di)二(?)阶(Jie)段(Duan)板(Ban)温(Wen)不(Bu)宜(Yi)过(Guo)高(Gao)。(?)为(Wei)了(Liao)提(Ti)高(Gao)第(Di)一(Yi)阶(Jie)段(Duan)的(De)升(Sheng)华(Hua)速(Su)度(Du),(?)可(Ke)将(Jiang)拉(La)板(Ban)温(Wen)度(Du)一(Yi)次(Ci)升(Sheng)高(Gao)至(Zhi)制(Zhi)品(Pin)允(Yun)许(Xu)的(De)温(Wen)度(Du)以(Yi)上(Shang);待(Dai)大(Da)量(Liang)升(Sheng)华(Hua)阶(Jie)段(Duan)基(Ji)本(Ben)结(Jie)束(Shu)时(Shi),(?)再(Zai)将(Jiang)板(Ban)温(Wen)降(Jiang)至(Zhi)允(Yun)许(Xu)的(De)温(Wen)度(Du),(?)这(Zhe)后(Hou)两(Liang)种(Zhong)方(Fang)式(Shi)虽(Sui)然(Ran)使(Shi)大(Da)量(Liang)的(De)升(Sheng)华(Hua)速(Su)度(Du)有(You)一(Yi)些(Xie)提(Ti)高(Gao),(?)但(Dan)其(Qi)抗(Kang)干(Gan)扰(Rao)的(De)能(Neng)力(Li)相(Xiang)应(Ying)降(Jiang)低(Di),(?)真(Zhen)空(Kong)度(Du)和(He)制(Zhi)冷(Leng)能(Neng)力(Li)的(De)突(Tu)然(Ran)降(Jiang)低(Di)或(Huo)停(Ting)电(Dian)都(Du)可(Ke)能(Neng)会(Hui)使(Shi)制(Zhi)品(Pin)融(Rong)化(Hua)。(?)合(He)理(Li)而(?)灵(Ling)活(Huo)地(Di)掌(Zhang)握(Wo)第(Di)一(Yi)种(Zhong)方(Fang)式(Shi),(?)仍(Reng)是(Shi)目(Mu)前(Qian)较(Jiao)常(Chang)用(Yong)的(De)方(Fang)式(Shi)。(?)